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TECHNOLOGY

The Mesoscale Challenge in Brain Mapping

Microscale

Microscale

Single neurons
Microscale

Mesoscale

Brain circuits
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Macroscale

Brain regions

Traditional neurotechnologies limit brain mapping to either fine detail but in very few neurons at a time (microscale), or in large regions but without the detail of their individual neurons (macroscale).

To truly understand how the brain functions, we need technologies that can map neural circuit activity at the mesoscale, i.e in thousands of individual neurons simultaneously during a cognitive or behavioral task. Enter Inscopix.

Inscopix Miniature Microscope:
The world's smallest brain observatory

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The innovation at the core of the Inscopix brain-mapping platform is the integration and miniaturization of the bulky bench-top fluorescence microscope (Left) into a 2 gm device (Right), smaller than a fingertip, that can be mounted onto the skull of a living animal subject to observe its brain activity.

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How the Miniscope Works

When a neuron is activated, calcium levels increase inside the cell. GCaMP6 binds to the calcium and reports the event by producing a transient fluorescent signal. The miniature microscope captures the changes in brain cell fluorescence and transmits high-resolution images through a flexible cable and data acquisition (DAQ) box, which can be accessed remotely to control the acquisition and stream the data live (see below).

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The Miniscope in Action

Miniature Microscope in action


Imaging the thinking, working brain (right) of a freely behaving mouse (left). The miniature microscope enables cellular resolution and cell-type specific GCaMP6 imaging in ~1,200 excitatory CA1 hippocampal neurons during active behavior over months.
Courtesy: Schnitzer Lab, Stanford

The Complete Solution

The Inscopix miniature microscope is the core of an end-to-end integrated platform that empowers researchers to catalyze
ground-breaking neuroscience discoveries with speed and scientific rigor.

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Biological Reagents

Our ready-to-image biological reagents, GCaMP6 carrying viruses, enable researchers to hit the ground running with nVista and nVoke.
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Instrumentation

The miniscope is the foundational technology for our nVista (activity imaging) and nVoke (activity imaging and manipulation) products.
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Neuroinformatics

Our data processing software helps researchers to derive insights from nVista and nVoke experiments faster by converting video datasets into activity traces.
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Explore Inscopix miniscope technology

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