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Integrated Calcium Imaging & Optogenetics


Measure and Manipulate Brain Circuit Dynamics

In vivo. Simultaneously. During behavior. 

nVoke in Action

nVoke workflow for calcium imaging (GCaMP6) in striatal medium spiny neurons and optogenetic inhibition of adjacent inhibitory interneurons (Left). Workflow from basolateral amygdala-nucleus accumbens pathway stimulation during place-preference behavioral paradigm (Right). 

nVoke Advantages

nVoke integrates simultaneous calcium imaging with optogenetic manipulation, empowering scientists to causally link neural activity within brain circuits to behavior.  

  • Enables simultaneous cellular-resolution calcium imaging & optogenetic manipulation in freely moving animals    
  • Record the same field of view longitudinally with electronic focusing
  • Integrate nVoke and multimodal inputs with automated control and precise timing 

nVoke Applications

nVoke integrates two LED light sources for simultaneous or sequential cellular resolution imaging using GCaMP indicators and red-shifted opsins* for temporally precise control of cells within the same field of view. Using common spectrally-matched indicator and opsin combinations*, you can now test causal relationships between calcium dynamics and behavior.

* validated opsin/indicator combinations display minimal biological cross-talk with maximized signal-to-noise.  

nVoke Applications

Validated in vivo by Leading Circuit Neuroscientists

Read publications with nVoke

The MIRA Platform

The Inscopix Multimodal Image Registration and Analysis (MIRA) platform enables multimodal data collection and registration of unique cells across data sets to integrate freely-behaving calcium imaging data with high-resolution multicolor data, enabling new functional discoveries in circuit neuroscience.

  • Combine the power of freely-behaving imaging with the precision of laser scanning microscopes 
  • Collect more information about the cells of interest with dual-color imaging
  • Compare calcium activity between freely-behaving and head-fixed conditions
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Consumables & Accessories

We strive to provide everything you need to accelerate your experiments so that you can spend more time engaging with the data. Learn about our growing portfolio of solutions for circuit neuroscience, including ready-to-image viruses and GRIN lenses for all brain regions.

Data Processing Software

Our data processing software transforms raw video data into neural activity insights! 

  • Intuitive Interface: Streamline your analysis with our complete & validated pipeline to extract traces and events from your longitudinal recordings. 

  • Integrated Visualization: See the full picture simultaneously through integrated visualization of your calcium movies, traces and events, and behavioral recordings. 

  • APIs: Process your data with algorithms from Inscopix Data Processing Software in Matlab or Python

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Learn how Inscopix supports your research

Meet the support team