Integrated Calcium Imaging and Optogenetics

The integration of in vivo cellular-resolution calcium imaging with simultaneous or sequential optogenetic manipulation is enabled by the nVokeTM System to causally link neural circuit activity with behavior.

  • Record cellular-resolution calcium imaging with optogenetic manipulation
  • Visualize and manipulate the same field of view longitudinally
  • Study the impact of discrete manipulation on behavior and its underlying network dynamics
Optogenetics

Inscopix Data Processing

Streamline your miniscope data analysis with the Inscopix Data Processing Software (IDPS), our complete and validated pipeline with no required scripting expertise.

  • Identify unique cells and extract Ca2+ traces easily using PCA/ICA or Inscopix CNMFe
  • Automatically filter identified cells by setting SNR and cell-size criteria
  • Perform longitudinal registration to identify the same cells over days or multiplane registration to identify unique cells in up to three planes

The nVoke System

The nVoke System integrates in vivo calcium imaging with simultaneous or sequential optogenetic manipulation to measure and manipulate brain circuit dynamics.

The nVoke system is exactly what we needed to link changes in activity of interneurons to calcium signaling in striatal output neurons. It enabled us to formulate a new hypothesis about how fast-spiking interneurons function to regulate motor behavior.

Anatol Kreitzer
Gladstone Institute, UCSF

nVoke System Research Highlights

Searching for Network-Level Patterns of Activity within Prefrontal Circuits

Decoding the network level patterns of prefrontal activity during anxiety-related and social behaviors. Dr. Sohal at UCSF describes his approaches to it.

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Neural Circuit Mechanisms of Striatal Motor Learning

Dr. Anatol Kreitzer talks about his stunning Cell paper that sheds new light on the neural circuit mechanisms of striatal motor learning.

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The Complete Solution

Our end-to-end solutions enable you to manipulate and measure neural circuit dynamics during free behavior to help you make your next breakthrough!

Calcium Imaging With Optogenetic Manipulation

Lenses & Viruses

Our advanced workflow solutions include fully integrated GRIN lenses with virus to simplify the workflow to single step or individually optimized viruses and lenses to accelerate your circuit neuroscience research.

Support

From experimental design to data analysis, from grant to manuscript submissions, our world-class scientific support team stands ready to assist you every step of the way.

nVoke System

Measure and manipulate brain circuit dynamics with the nVoke by integrating in vivo cellular-resolution calcium imaging with simultaneous or sequential optogenetic manipulation.

Software & Analysis

We offer a comprehensive range of options to acquire and process raw calcium imaging videos with your Inscopix system purchase.

Request a Quote

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