Learn about nVoke  

nVoke

Integrated calcium imaging & optogenetics

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Measure & manipulate brain circuit dynamics

In vivo. Simultaneously. During behavior.

State-of-the-art for demonstrating causality

nVoke combines cellular-resolution calcium imaging and full-field optogenetics into a single head-mounted miniature microscope that empowers you to causally link neural dynamics in specific cell-types and circuits in the mouse brain with emergent behavior.

Applications

 

SAME CELLS1

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TWO POPULATIONS1

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TWO POPULATIONS2

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Ca2+ IMAGING
+
OPTOEXCITATION*
UNDER
VALIDATION
UNDER
VALIDATION 
✔   VALIDATED
GCaMP6 + ChrimsonR
Ca2+ IMAGING
+
OPTOINHIBITION*
✔   VALIDATED
GCaMP6 + NpHR3.0/Jaws
✔   VALIDATED
GCaMP6 + NpHR3.0/Jaws
✔   VALIDATED
GCaMP6 + NpHR3.0/Jaws


nVoke AppInd.png  Calcium Indicator (GCaMP6)                 nVoke AppOpsin.png  Opsin (ChrimsonR, NpHR3.0, Jaws)                 *Sequential & Simultaneous                 1Somal Optogenetics                2Terminal Optogenetics

See research areas

nVoke in action

Workflow for somal calcium imaging (GCaMP6) in nucleus accumbens (NAc) neurons and terminal optogenetic excitation (Chrimson) of basolateral amygdala (BLA) neurons (Left). Video from BLA-NAc pathway stimulation during place-preference behavioral paradigm (Right). 

Validated in vivo by leading circuit neuroscientists

Read case studies

Consumables & accessories

We strive to provide everything you need to accelerate your experiments so that you can spend more time engaging with the data. Learn about our growing portfolio of solutions for circuit neuroscience, from viruses, to GRIN lenses, and surgical instruments:

Data analysis

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Mosaic, our data analysis software helps turn your raw video data into insights faster with: 

  • Simple and intuitive GUI

  • Streamlined work flow from image processing to event detection

  • Integrated visualization for brain imaging, traces, and animal behavior

Inscopix Mosaic Software Workflow

Request a quote

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Resources

View technical specifications for nVoke

View specification sheet

Read case studies from scientists using our cutting-edge nVoke technology in their own labs.

Read case studies

View data videos, customer profile videos, interviews with industry thought leaders, and more.

Watch videos

iCare is our complete system repair and replacement expanded warranty program. iCare expands coverage to failures caused by an operator or animal subject (such as damaged cables or broken objectives) on a priority basis, with expedited shipment, and all costs included. iCare ensures that you experience minimal downtime between experiments and safeguards against unexpected maintenance costs.

At Inscopix, we view technology as means to an end. Our mission is to empower to you with cutting-edge neurotechnologies and then help you apply them to your research with speed and scientific rigor. Learn more about our training workshops, online knowledge base, and world-class team of scientific consultants dedicated to putting you on an accelerated path to scientific success. Learn more

Ready for integrated imaging & optogenetics?

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