Publications

Advancing circuit neuroscience through technological innovation

Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice

In a recent study by Kyohei Kin et al., the impact of adolescent psychosocial stress on postpartum social behavior was examined. Using innovative techniques such as optogenetics and in vivo microendoscopic calcium imaging with the inscopix nVoke system, the researchers…

May 23, 2023

Dopamine error signal to actively cope with lack of expected rewards

Rewards are often elusive and uncertain, requiring persistent effort to obtain. But how do we…

March 10, 2023

Longitudinal Monitoring of Prefrontal Cortical Ensemble Dynamics Reveals New Insights into Stress Habituation

The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been…

September 3, 2022

A molecularly defined D1 medium spiny neuron subtype negatively regulates cocaine addiction

The striatum plays a critical role in regulating addiction-related behaviors. The…

August 12, 2022

Neural circuit pathology driven by Shank3 mutation disrupts social behaviors

Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from…

June 7, 2022

Most recent

Calcium imaging of basal forebrain activity during innate and learned behavio

The basal forebrain (BF) plays crucial roles in arousal, attention, and memory, and its impairment is associated with a variety of cognitive deficits. The BF consists…

May 9, 2016

Neurons for hunger and thirst transmit a negative-valence teaching signal

Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis…

April 27, 2016

Large-scale fluorescence calcium-imaging methods for studies of long-term memory in behaving mammals

During long-term memory formation, cellular and molecular processes reshape how individual neurons respond to specific patterns of synaptic input. It remains poorly…

April 5, 2016

Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice

Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior…

February 29, 2016

Calcium imaging of sleep–wake related neuronal activity in the dorsal pons

The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using…

February 25, 2016

Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses

Genetically encoded calcium indicators for visualizing dynamic cellular activity have greatly expanded our understanding of the brain. However, owing to the…