Cellular level brain imaging in behaving mammals: an engineering approach
Fluorescence imaging offers expanding capabilities for recording neural dynamics in behaving mammals, including the means to monitor hundreds of cells targeted by…
Hamel EJO et al. | Neuron | April 8, 2015
Cell-type-specific activity in prefrontal cortex during goal-directed behavior
The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether…
Pinto L et al. | Neuron | February 7, 2015
Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors
Optimally orchestrating complex behavioral states, such as the pursuit and consumption of food, is critical for an organism's survival. The lateral hypothalamus (LH) is…
Jennings JH et al. | Cell | January 29, 2015
Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope
Therapeutic drugs for cognitive and psychiatric disorders are often characterized by their molecular mechanism of action. Here we demonstrate a new approach to elucidate…
Berdyyeva T et al. | PLOS ONE | November 5, 2014
Tools for resolving functional activity and connectivity within intact neural circuits
Mammalian neural circuits are sophisticated biological systems that choreograph behavioral processes vital for survival. While the inherent complexity of discrete neural…
Jennings JH et al. | Current Biology | January 6, 2014
Imaging neuronal populations in behaving rodents: paradigms for studying neural circuits underlying behavior in the mammalian cortex
Understanding the neural correlates of behavior in the mammalian cortex requires measurements of activity in awake, behaving animals. Rodents have emerged as a powerful…
Chen JL et al. | The Journal of Neuroscience | November 6, 2013