Amygdala ensembles encode behavioral states
Internal states, including affective or homeostatic states, are important behavioral motivators. The amygdala regulates motivated behaviors, yet how distinct states are…
Gründemann J et al. | Science | April 19, 2019
A gut-to-brain signal of fluid osmolarity controls thirst satiation
Satiation is the process by which eating and drinking reduce appetite. For thirst, oropharyngeal cues have a critical role in driving satiation by reporting to the brain…
Zimmerman CA et al. | Nature | March 27, 2019
Cholinergic modulation of hippocampal calcium activity across the sleep-wake cycle
Calcium is a critical second messenger in neurons that contributes to learning and memory, but how the coordination of action potentials of neuronal ensembles with the…
Zhou H et al. | eLife | March 7, 2019
In vivo calcium imaging reveals that cortisol treatment reduces the number of place cells in Thy1-GCaMP6f transgenic mice.
The hippocampus, a structure essential for spatial navigation and memory undergoes anatomical and functional changes during chronic stress. Here, we investigate the…
Indersmitten T et al. | Frontiers in Neuroscience | March 1, 2019
Divergent medial amygdala projections regulate approach–avoidance conflict behavior
Avoidance of innate threats is often in conflict with motivations to engage in exploratory approach behavior. The neural pathways that mediate this approach–avoidance…
Miller SM et al. | Nature Neuroscience | February 25, 2019
A hypothalamus-habenula circuit controls aversion
Encoding and predicting aversive events are critical functions of circuits that support survival and emotional well-being. Maladaptive circuit changes in emotional…
Lazaridis I et al. | Molecular Psychiatry | February 12, 2019