Complete representation of action space and value in all striatal pathways
The dorsal striatum plays a central role in motor and decision programs, such as the selection and execution of particular actions and the evaluation of their outcomes.…
Weglage M et al. | | March 29, 2020
Action representation in the mouse parieto-frontal network
The posterior parietal cortex (PPC) and frontal motor areas comprise a cortical network supporting goal-directed behaviour, with functions including sensorimotor…
Tombaz T et al. | Scientific Reports | March 27, 2020
Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation
Appropriate motor control is critical for normal life, and requires hypothalamic hypocretin/orexin neurons (HONs). HONs are slowly regulated by nutrients, but also…
Karnani MM et al. | Progress In Neurotechnology | February 11, 2020
Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum
Projections from the nucleus accumbens to the ventral pallidum (VP) regulate relapse in animal models of addiction. The VP contains GABAergic (VPGABA) and glutamatergic…
Heinsbroek JA et al. | Cell Reports | February 11, 2020
Persistent Activation of Central Amygdala CRF Neurons Helps Drive the Immediate Fear Extinction Deficit
Fear extinction is an active learning process whereby previously established conditioned responses to a conditioned stimulus are suppressed. Paradoxically, when…
Jo YS et al. | Nature Communications | January 22, 2020
Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine (DA) neurons, has been hypothesized to be broadly activated by aversive stimuli.…
Li H et al. | eLife | January 22, 2020