Inscopix’s nVoke product for simultaneous imaging and optogenetics empowers researchers to dissect how different groups of neurons, whether intermixed in microcircuits or separated across brain regions, exert directional and causal influence on each other to shape the computations that underlie cognition and behavior.
They use nVoke, an integrated one-photon cellular-resolution Ca2+ imaging & optogenetic system, to investigate the causal link between the basolateral amygdala to nucleus accumbens circuit in freely-behaving mice. The ability to perform optogenetics and Ca2+ imaging in the same field of view opens up possibilities to test sophisticated causal hypotheses that link neural circuit dynamics with behavior, system states, and plasticity.
The basal ganglia
nVoke has made it possible for us to measure how optogenetic inhibition alters multineuronal patterns of activity in freely behaving mice. This is leading us to a previously unattainable understanding of the links between the activity of a specific subtype of mPFC neurons, multineuronal patterns of activity, and behavior.
- Vikaas Sohal, PhD, UCSF
The nVoke system gave us an unprecedented ability to simultaneously activate DA terminals while recording activity in anatomically-defined neurons in a freely-moving animal.
- Kay Tye, PhD, MIT