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CONNECTIVITY MAPPING

Deciphering pathways of information flow in the brain

Inscopix’s nVoke product for simultaneous imaging and optogenetics empowers researchers to dissect how different groups of neurons, whether intermixed in microcircuits or separated across brain regions, exert directional and causal influence on each other to shape the computations that underlie cognition and behavior.

RESEARCH HIGHLIGHT

Investigating the VTA mPFC reward circuit during free behavior

The nVoke system gave us an unprecedented ability to simultaneously activate DA terminals while recording activity in anatomically-defined neurons in a freely-moving animal.

- Kay Tye, PhD, MIT 

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RESEARCH HIGHLIGHT

Assessing microcircuit function in the dorsal striatum

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The nVoke system is exactly what we needed to link changes in activity of interneurons to calcium signaling in striatal output neurons. It enabled us to formulate a new hypothesis about how fast-spiking interneurons function to regulate motor behavior.

- Anatol Kreitzer, PhD, UCSF

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RESEARCH HIGHLIGHT

Assessing microcircuit function in the medial prefrontal cortex

nVoke has made it possible for us to measure how optogenetic inhibition alters multineuronal patterns of activity in freely behaving mice. This is leading us to a previously unattainable understanding of the links between the activity of a specific subtype of mPFC neurons, multineuronal patterns of activity, and behavior. 

- Vikaas Sohal, PhD, UCSF

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RESEARCH HIGHLIGHT

Dissecting inter-regional functional connectivity between BLA & NAc

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With the nVoke platform, we are for the first time able to
reveal how influencing communication between the BLA – NAc functionally drives network activity & behavioral expression in vivo.

- Alice Stamatakis, PhD, Inscopix

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