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CONNECTIVITY MAPPING

Deciphering pathways of information flow in the brain

Inscopix’s nVoke product for simultaneous imaging and optogenetics empowers researchers to dissect how different groups of neurons, whether intermixed in microcircuits or separated across brain regions, exert directional and causal influence on each other to shape the computations that underlie cognition and behavior.

RESEARCH HIGHLIGHT

Deciphering the role of striatal fast-spiking interneurons
in motor learning

The basal ganglia is involved in motor control and motor learning. In this study, Dr. Anatol Kreitzer (UCSF/Gladstone Institutes) and colleagues hypothesized that fast-spiking interneurons (FSI) in the striatum regulate motor control, but instead discovered an unexpected role in motor learning. The researchers then used nVoke to show that FSI influence motor learning by regulating calcium influx and synaptic plasticity in the principal output neurons of the striatum, the medium spiny neurons.

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RESEARCH HIGHLIGHT

Investigating the VTA mPFC reward circuit during free behavior

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The nVoke system gave us an unprecedented ability to simultaneously activate DA terminals while recording activity in anatomically-defined neurons in a freely-moving animal.

- Kay Tye, PhD, MIT 

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RESEARCH HIGHLIGHT

Assessing microcircuit function in the medial prefrontal cortex

nVoke has made it possible for us to measure how optogenetic inhibition alters multineuronal patterns of activity in freely behaving mice. This is leading us to a previously unattainable understanding of the links between the activity of a specific subtype of mPFC neurons, multineuronal patterns of activity, and behavior. 

- Vikaas Sohal, PhD, UCSF

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RESEARCH HIGHLIGHT

Dissecting inter-regional functional connectivity between BLA & NAc

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With the nVoke platform, we are for the first time able to
reveal how influencing communication between the BLA – NAc functionally drives network activity & behavioral expression in vivo.

- Alice Stamatakis, PhD, Inscopix

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