A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations
Successful recall of a contextual memory requires reactivating ensembles of hippocampal cells that were allocated during memory formation. Altering the ratio of…
He L et al. | Neuron | May 18, 2022Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning
How are actions linked with subsequent outcomes to guide choices? The nucleus accumbens, which is implicated in this process, receives glutamatergic inputs from the…
Parker NF et al. | Cell Reports | May 17, 2022The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels
Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H3 receptor (H3R) antagonists/inverse agonists enhance…
Hirano K et al. | Scientific Reports | May 12, 2022Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition
Prefrontal cortex (PFC) is postulated to exert “top-down control” on information processing throughout the brain to promote specific behaviors. However, pathways…
Malik R et al. | Cell | April 28, 2022Encoding of environmental cues in central amygdala neurons during foraging
To successfully forage in an environment filled with rewards and threats, animals need to rely on familiar structures of their environment that signal food availability…
Ponserre M et al. | The Journal of Neuroscience | April 5, 2022A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation
Memories encoded in the dentate gyrus (DG) ‒ CA3 circuit of the hippocampus are routed from CA1 to anterior cingulate cortex (ACC) for consolidation. Although CA1…
Twarkowski H et al. | eLife | February 22, 2022