Dynamic dichotomy of accumbal population activity underlies cocaine sensitization
Locomotor sensitization (LS) is an early behavioral adaptation to addictive drugs, driven by the increase of dopamine in the Nucleus Accumbens (NAc). However, the effect…
Zessen Rv et al. | eLife | October 5, 2021
Microendoscopic calcium imaging of the primary visual cortex of behaving macaques
In vivo calcium imaging with genetically encoded indicators has recently been applied to macaque brains to monitor neural activities from a large population of cells…
Oguchi M et al. | Scientific Reports | August 23, 2021
Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity
Antipsychotic-induced dopamine supersensitivity, or behavioral supersensitivity, is a problematic consequence of long-term antipsychotic treatment characterized by the…
Kruyer A et al. | Molecular Psychiatry | August 4, 2021
Optical deep-cortex exploration in behaving rhesus macaques
Non-human primates (NHPs) are important animal models for understanding higher brain functions relevant to complex human behaviors including cognition and motor control…
Matsuzaki M et al. | Nature Communications | August 2, 2021
Miniature microscopes for manipulating and recording in vivo brain activity
Here we describe the development and application of miniature integrated microscopes (miniscopes) paired with microendoscopes that allow for the visualization and…
Stamatakis AM et al. | Microscopy | August 2, 2021
Complete representation of action space and value in all dorsal striatal pathways
The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and…
Weglage M et al. | Cell Reports | July 27, 2021