Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior
Precise neural sequences are associated with the production of well-learned skilled behaviors. Yet, how neural sequences arise in the brain remains unclear. In songbirds…
Daliparthi VK et al. | eLife | June 11, 2019
A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors
Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and…
Shi G et al. | Neuron | May 28, 2019
Engram-specific transcriptome profiling of contextual memory consolidation
Sparse populations of neurons in the dentate gyrus (DG) of the hippocampus are causally implicated in the encoding of contextual fear memories. However, engram-specific…
Rao-Ruiz P et al. | Nature Communications | May 20, 2019
Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons
Craving for cocaine progressively increases in cocaine users during drug-free periods, contributing to relapse. The projection from the infralimbic cortex to the nucleus…
Cameron CM et al. | Neuron | May 14, 2019
VIP interneurons contribute to avoidance behavior by regulating information flow across hippocampal-prefrontal networks
Inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are known to disinhibit cortical neurons. However, it is unclear how disinhibition, occurring…
Lee AT et al. | Neuron | April 30, 2019
Dynamic network activation of hypothalamic MCH neurons in REM sleep and exploratory behavior
Most brain neurons are active in waking, but hypothalamic neurons that synthesize the neuropeptide melanin-concentrating hormone (MCH) are claimed to be active only…
Blanco-Centurion C et al. | J Neuroscience | April 29, 2019