Pcdhβ deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination
Clustered protocadherins (Pcdhs), a large group of adhesion molecules, are important for axonal projections and dendritic spread, but little is known about how they…
Asai H et al. | Molecular Brain | January 20, 2020
Opposing Somatic and Dendritic Expression of Stimulus-Selective Response Plasticity in Mouse Primary Visual Cortex
Daily exposure of awake mice to a phase-reversing visual grating stimulus leads to enhancement of the visual-evoked potential (VEP) in layer 4 of the primary visual…
Kim T et al. | Frontiers in Cellular Neuroscience | January 14, 2020
Amygdala Reward Neurons Form and Store Fear Extinction Memory
The ability to extinguish conditioned fear memory is critical for adaptive control of fear response, and its impairment is a hallmark of emotional disorders like post-…
Zhang X et al. | Neuron | January 14, 2020
Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening
Functional coupling between the amygdala and the dorsomedial prefrontal cortex (dmPFC) has been implicated in the generation of negative affective states; however, the…
Marcus DJ et al. | Neuron | January 13, 2020
Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
The prefrontal cortex (PFC) is implicated in processing of the affective state of others through non-verbal communication. This social cognitive function is thought to…
Scheggia D et al. | Nature Neuroscience | December 16, 2019
A cortical-brainstem circuit predicts and governs compulsive alcohol drinking
What individual differences in neural activity predict the future escalation of alcohol drinking from casual to compulsive? The neurobiological mechanisms that gate the…
Siciliano CA et al. | Science | November 22, 2019