Intercalated amygdala clusters orchestrate a switch in fear state
Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive…
Hagihara KM et al. | Nature | May 26, 2021
iHELMET: A 3D-printing solution for safe endoscopic Ca2+ recording in social neuroscience
In vivo calcium imaging using a microendoscope is a state-of-the-art technique to study the cellular activity inside the brain of freely moving animals such as mice or…
Saxena K et al. | Journal of Neuroscience Methods | May 1, 2021
Single cell plasticity and population coding stability in auditory thalamus upon associative learning
Cortical and limbic brain areas are regarded as centres for learning. However, how thalamic sensory relays participate in plasticity upon associative learning, yet…
Taylor JA et al. | Nature Communications | April 26, 2021
The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia
The eating disorder anorexia nervosa is potentially fatal but also poorly understood. Sweeney et al. now show that AgRP (Agouti-related protein)–expressing neurons,…
Sweeney P et al. | Science Translational Medicine | April 21, 2021
Network dynamics of hypothalamic feeding neurons
Paraventricular nucleus (PVN) neurons expressing the melanocortin 4 receptor (MC4R) integrate hormonal and neuronal information concerning energy availability and engage…
Sweeney P et al. | PNAS | April 6, 2021
Calcium imaging of adult-born neurons in freely moving mice
Adult-born neurons (ABNs) in the dentate gyrus bestow unique cellular plasticity to the mammalian brain. We recently found that the activity of ABNs during sleep is…
Carrier-Ruiz A et al. | STAR Protocols | March 19, 2021