The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels
Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H3 receptor (H3R) antagonists/inverse agonists enhance…
Hirano K et al. | Scientific Reports | May 12, 2022Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition
Prefrontal cortex (PFC) is postulated to exert “top-down control” on information processing throughout the brain to promote specific behaviors. However, pathways…
Malik R et al. | Cell | April 28, 2022Encoding of environmental cues in central amygdala neurons during foraging
To successfully forage in an environment filled with rewards and threats, animals need to rely on familiar structures of their environment that signal food availability…
Ponserre M et al. | The Journal of Neuroscience | April 5, 2022A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation
Memories encoded in the dentate gyrus (DG) ‒ CA3 circuit of the hippocampus are routed from CA1 to anterior cingulate cortex (ACC) for consolidation. Although CA1…
Twarkowski H et al. | eLife | February 22, 2022Bias-free estimation of information content in temporally sparse neuronal activity
Applying information theoretic measures to neuronal activity data enables the quantification of neuronal encoding quality. However, when the sample size is limited, a…
Sheintuch L et al. | PLOS Computational Biology | February 11, 2022Hippocampal-amygdala memory circuits govern experience-dependent observational fear
The empathic ability to vicariously experience the other’s fearful situation, a process called observational fear (OF), is critical to survive in nature and function in…
Terranova JI et al. | Neuron | February 8, 2022