Neurons for hunger and thirst transmit a negative-valence teaching signal
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis…
Betley JN et al. | Nature | April 27, 2016
Large-scale fluorescence calcium-imaging methods for studies of long-term memory in behaving mammals
During long-term memory formation, cellular and molecular processes reshape how individual neurons respond to specific patterns of synaptic input. It remains poorly…
Jercog P et al. | Cold Spring Harbor Perspectives In Biology | April 5, 2016
Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice
Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior…
Berdyyeva TK et al. | Frontiers in Neuroscience | February 29, 2016
Calcium imaging of sleep–wake related neuronal activity in the dorsal pons
The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-…
Cox J et al. | Nature Communications | February 25, 2016
Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses
Genetically encoded calcium indicators for visualizing dynamic cellular activity have greatly expanded our understanding of the brain. However, owing to the light-…
Resendez SL et al. | Nature Protocols | February 25, 2016
Hippocampal ensemble dynamics timestamp events in long-term memory
The capacity to remember temporal relationships between different events is essential to episodic memory, but little is currently known about its underlying mechanisms.…
Rubin A et al. | eLife | December 18, 2015