Unsupervised discovery of temporal sequences in high-dimensional datasets, with applications to neuroscience
Identifying low-dimensional features that describe large-scale neural recordings is a major challenge in neuroscience. Repeated temporal patterns (sequences) are thought…
Mackevicius EL et al. | eLife | February 5, 2019
Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses
Adaptive fear responses to external threats rely upon efficient relay of computations underlying contextual encoding to subcortical circuits. Brain-wide analysis of…
Besnard A et al. | Nature Neuroscience | February 4, 2019
Leveraging calcium imaging to illuminate circuit dysfunction in addiction
Alcohol and drug use can dysregulate neural circuit function to produce a wide range of neuropsychiatric disorders, including addiction. To understand the neural circuit…
Siciliano CA et al. | Alcohol | February 1, 2019
Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode
Survival depends on the selection of behaviors adaptive for the current environment. For example, a mouse should run from a rapidly looming hawk but should freeze if the…
Seo C et al. | Science | January 31, 2019
An amygdalar neural ensemble that encodes the unpleasantness of pain
Pain is an unpleasant experience. How the brain’s affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-…
Corder G et al. | Science | January 17, 2019
Activity Patterns in the Neuropil of Striatal Cholinergic Interneurons in Freely Moving Mice Represent Their Collective Spiking Dynamics
Cholinergic interneurons (CINs) are believed to form synchronous cell assemblies that modulate the striatal microcircuitry and possibly orchestrate local dopamine…
Rehani R et al. | eNeuro | January 4, 2019