Model-based behavioral control can predict future states based on chosen actions

Akam T et al. | Neuron | November 4, 2020

Functional clusters track parallel processing in direct and indirect pathways

Shin JH et al. | PNAS | October 27, 2020

Mouse fMRI reveals affective computations in a corticolimbic loop

Kargl D et al. | eLife | October 20, 2020

Identification of a key cellular component of sleep homeostasis in mice

Ingiosi AM et al. | Current Biology | September 24, 2020
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Slow neuronal dynamics encode threat responses for emotional memory

Kennedy A et al. | Nature | September 16, 2020
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Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states

The balance between exploiting known actions and exploring alternatives is critical for survival and hypothesized to rely on shifts in neuromodulation. We developed a…

Koralek AC et al. | Science Advances | July 23, 2021
Science Advances

Dentate granule cells encode auditory decisions after reinforcement learning in rats

Auditory-cued goal-oriented behaviors requires the participation of cortical and subcortical brain areas, but how neural circuits associate sensory-based decisions with…

Shen J et al. | Scientific Reports | July 13, 2021
Scientific Reports

Application of optogenetics and in vivo imaging approaches for elucidating the neurobiology of addiction

The neurobiology of addiction has been an intense topic of investigation for more than 50 years. Over this time, technological innovation in methods for studying brain…

Vickstrom CR et al. | Molecular Psychiatry | June 18, 2021

Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque

Microendoscopic calcium imaging with one-photon miniature microscopes enables unprecedented readout of neural circuit dynamics during active behavior in rodents. In this…

Bollimunta A et al. | Cell Reports | June 15, 2021

Corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis exhibit sex-specific pain encoding in mice

The bed nucleus of the stria terminalis (BNST) plays an emerging role in pain regulation. Pharmacological studies have found that inhibiting corticotropin-releasing…

Yu W et al. | Scientific Reports | June 14, 2021
Scientific Reports

A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing

Dysregulation in contextual processing is believed to affect several forms of psychopathology, such as post-traumatic stress disorder (PTSD). The dentate gyrus (DG), a…

Seo D et al. | Neuron | June 2, 2021

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Modulating D1 rather Yun S et al. | August 3, 2021

Overactive dopamine transmission in psychosis is predicted…

Transient dopamine Mendonça MD et al. | April 20, 2021

Dopamine neurons (DANs) in the substantia nigra pars…

Independent and distinct Manning EE et al. | March 3, 2021

Background Patients with obsessive-compulsive disorder (OCD…

An endogenous opioid Castro DC et al. | February 10, 2021

Mu-opioid peptide receptor (MOPR) stimulation alters…